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The additional 11 ADC clinical candidates that conjugate to cysteine utilize maleimide chemistry either to mc or mcc
[DOI] [PubMed] [Google Scholar] 61.Volek J.S., Kraemer W.J., Rubin M.R., Gomez A.L., Ratamess N.A., Gaynor P
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However, during high-fat diet (HFD) feeding, obesity and insulin resistance, the accumulation of medium-chain and long-chain acylcarnitines due to incomplete -oxidation may negatively regulate the expression of nuclear-encoded mitochondrial genes, further reducing mitochondrial number and function and creating a vicious metabolic cycle [33]
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