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Tier 2 conditions in detail: Heart failure with preserved ejection fraction (HFpEF) HFpEF is heart failure with a left ventricular ejection fraction of 50 percent or higher on echocardiogram

doi: 10.1016/j.crneur.2022.100028 394 YanX.KusterD.MohantyP.NijssenJ.Pombo-GarcaK.Garcia MoratoJ.et al

Secretin exerts its effects by binding to a specific receptor, the secretin receptor (SR) which is a GPCR of the class B secretin-like family of receptors

The Journal of nutrition , 153 (5), 13051308