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Cocaine Only limited clinical evidence is available for GLP-1RAs in cocaine misuse: a small ( N = 13) proof-of-concept trial across 2 days showed that exenatide compared with placebo did not reduce the number of self-administered cocaine infusions 115 , while a case series of 3 individuals with cocaine-use disorder highlighted the feasibility and safety of using the same drug over 6 weeks, although no efficacy measures were reported 116

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Semaglutide and the future of obesity care in the UK

The result is that a much higher proportion of administered IGF-1 DES reaches target tissue receptors compared to an equivalent amount of full-length IGF-1, explaining the approximate 10-fold potency advantage