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The selective mechanism that avoids systemic hormonal disruption suggests potential for extended use compared to interventions that create metabolic or endocrine imbalances requiring periodic breaks

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Further, we will use our equitable adjustment authority under section 1833(t)(2)(E) of the Act to maintain the CY 2025 payment rate of $4.69 per mm2 for HCPCS code C2645, which we are assigning to APC 2648 (Brachytx planar, p1-103), for CY 2026

Dosing frequency depends on the specific GLP-1 prescribed: Once-daily injections (e } What to Expect After Starting GLP-1 Injections Its common for licensed providers to start patients at a lower dose, which may minimize side effects and build tolerance