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PMID 16527179

10.1093/eurheartj/ehr224 8 BouitbirJ.SinghF.CharlesA.-L.SchlagowskiA.-I.BonifacioA.Echaniz-LagunaA.et al (2016)

The global surge in type 2 diabetes, which is largely driven by sedentary behavior, nutritional transitions, and rapid urbanization, has paralleled the rising incidence of DKD, as underscored by recent reports from the International Diabetes Federation (IDF) and the World Health Organization (WHO) (Figure 2) (Pereira et al., 2022

Patients should use it under medical supervision, and both patients and providers should report any adverse effects just as they would with commercially approved drugs