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The primary role of GSTs is to detoxify xenobiotics by catalyzing the nucleophilic attack by GSH on electrophilic carbon, sulfur, or nitrogen atoms of said nonpolar xenobiotic substrates, thereby preventing their interaction with crucial cellular proteins and nucleic acids

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Altered molecular genetic pathways may also contribute to the effects of oxidative stress in the pathogenesis of endometriosis and endometriosis-associated infertility

Besides, goiter may be experimentally induced in animals exposed to goitrogenic substances, like perchlorate or thiocyanates, which block iodine uptake in the thyroid gland, causing a similar compensatory rise in secretion of TSH and hyperplasia of thyroid cells (Nourani and Sadr 2023)