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In 2022, Holzer et al

Consistent timing each day enhances the medications effectiveness

For example, one Iranian study used 55 mg of zinc sulphate (~15 mg elemental zinc) each day and saw reduction in hyperactivity

Previous reports that megadoses of vitamin C destroy vitamin B 12 have not been supported (147) and may have been an artifact of the assay used to measure vitamin B 12 status (21)