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First, it works through beta-3 adrenergic receptors, which are predominantly expressed in adipose tissue with limited expression in most other tissues

Factors such as a disrupted gut microbiome and underlying infections, nutrient deficiencies such as magnesium, calcium and vitamin D as well as food sensitivities can cause joint and muscle pain in those with hyperthyroidism

FOXO4-DRI has a rapidly expanding and high-impact published research base, with studies published across Nature, Nature Communications, Communications Biology, Aging, Frontiers in Bioengineering and Biotechnology, and PMC since its foundational description in 2017

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