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While human evidence is still limited, the warning remains due to: persistent concern about thyroid proliferation lack of long-term human safety data increased calcitonin levels in some patients Related: Black Box Warnings Potential Long-Term Neurological Effects Because GLP-1 receptors exist in the brain, long-term use may influence: mood regulation cognition reward systems appetite pathways Emerging reports suggest possible risks: depression anxiety emotional blunting reduced hunger signaling long-term Research is ongoing

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