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The addition of vitamin B6, which is part of many enzymes involved in metabolism, as well as directly involved in the metabolism of carbohydrates (the formation and decomposition of muscle glycogen) and fat, additionally increasing energy acquisition

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In 56-week studies, patients taking Contrave alongside diet and exercise lost an average of 5-9% of their body weight, compared to 1-5% with a placebo, meaning the medication contributed roughly 4-5 percentage points of additional weight loss.4,5 About 46% of patients on Contrave achieved at least 5% weight loss by week 16