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Clin Chim Acta 308:5557 Ryan S, Bacon H, Endenburg N, Hazel S, Jouppi R, Lee N, Seksel K, Takashima G (2019) WSAVA animal welfare guidelines

These findings came from one research programme and require consideration of mouse strain, housing conditions, dose pattern and statistical methods

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One study on women looking at colon cancer risk found that women with a high polygenic risk score for colon cancer had a significant reduction in risk of CRC with menopausal HRT.[ref] Another study showed that several genetic variants statistically impacted the risk of breast cancer with HRT, but it concluded that more studies are needed