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275 Inflammatory molecular signalling pathways in both the central nervous system and the periphery can affect brain connections and synaptic function by affecting components including microglia, complement factors, cytokines and their receptors, MET receptors, and major histocompatibility complex class I molecules (MHCI) (Fig

doi: 10.1210/en.2013-1934 29 MuscogiuriGDeFronzoRAGastaldelliAHolstJJ

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Lipid peroxidation of the mitochondrial membrane produces toxic molecules such as 4-hydroxynonenal and malondialdehyde, which in turn disturb mitochondrial membrane fluidity.108109 The impaired mitochondrial membrane leads to dysregulation in ionic balances and excessive intracellular calcium influx, which consequently causes neuronal death and impairs synaptic plasticity.110111112 NEUROPROTECTIVE AND ANTI-INFLAMMATORY THERAPY IN SCHIZOPHRENIA Randomized controlled trials have investigated the efficacy of adjuvant COX-2 inhibitor on antipsychotics treatment in schizophrenia