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Silencing CHAC1 in TRIB3-deficient cells restores GSH levels and reduces arsenite-induced cell death, highlighting the critical role of the TRIB3/CHAC1 axis in regulating cell survival under arsenite stress (Figure 2) (rd et al., 2016)

384,385 Additionally, GWAS has identified several novel genetic loci associated with DPN, underscoring the complex genetic architecture underlying this condition