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Of pathophysiological importance, circulating cholesterol is a major component of atherosclerotic plaques [64]

A short, simple peptide like KPV (just three amino acids) tends to be more stable than a longer, complex peptide with multiple sensitive residues

Physiological melanin hyperpigmentation is the result of increased melanin biosynthesis by melanocytes in the basal cell layer of the oral epithelium, but pathological melanin pigmentation may be the result of increased number of normal melanocytes or atypical melanocytes, of increased melanogenic activity of normal or atypical melanocytes, or of both

148,149 The Met-358 is at the P1 position, which is located in the reactive site, and determines anti-protease activity of AAT