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A 2025 Springer review on the topic confirmed that women with PCOS face unique metabolic challenges, including heightened insulin resistance, compounded by obesity that require targeted, not generic, interventions

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Real-time PCR Total RNA was extracted with TRIzol and reverse transcribed to cDNA as directed in the RT-PCR Kit (ThermoFisher Scientific, Waltham, MA, USA) used here

Studies reported effects of SGLT2i or GLP-1RAs in children or adolescents were excluded from the analysis