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Oxidative stress contributes to metastasis by influencing multiple steps of the metastatic cascade, including epithelial-mesenchymal transition (EMT), invasion, intravasation, survival in the circulation, extravasation, and colonization of distant organs [118]

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doi: 10.1089/ars.2006.8.1865

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The current understanding is built upon a large body of preclinical evidence from animal studies on similar connective tissues

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