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Hence, targeting oxidative stress in IBD diagnosis emerges as a promising avenue with far-reaching implications

They act on two different receptors that converge on the same outcome, which is why pairing them produces a more complete signal than either one alone

MI functions as both a gut-modulated metabolite and an insulin sensitizer

Mechanistically, autoantibodies and interferon- present in the serum induce neutrophil ferroptosis through enhanced binding of the transcriptional repressor CREM to the glutathione peroxidase 4 ( Gpx4 , the key ferroptosis regulator) promoter, which leads to suppressed expression of Gpx4 and subsequent elevation of lipid-reactive oxygen species