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Recent studies have further revealed that ACSL4 is highly expressed in the fibroblasts of the IBD gut, actively secreting phospholipids rich in PUFAs, which, upon uptake by epithelial cells, lower the threshold for ferroptosis, thus forming a cross-cellular ROS network between fibroblasts, epithelial cells, myeloid cells, and endothelial cells [146]

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doi: 10.3390/toxics2020327 166 MarangiG.TraynorB

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Key takeaways: L-glutathione is a powerful, natural antioxidant

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Acne vulgaris: a review of the pathophysiology, treatment, and recent nanotechnology based advances

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