Animals tests for acute skin irritation assessment usually follow the Draize rabbit test while other accepted assays for skin sensitization include Local Lymph Node Assay (LLNA) and Guinea Pig Maximisation Test (GPMT)
Common Ozempic side effects include: Weight loss Gastrointestinal symptoms, such as nausea, constipation, diarrhea, and abdominal pain Eye symptoms, such as diabetic retinopathy Low blood sugar, characterized by lightheadedness Injection site reactions, such as pain or redness Serious side effects include: Thyroid tumors Angioedema (swelling of tissues in the face, eyes, and lips) Acute kidney injury Worsening of kidney disease Pancreatitis (inflammation of the pancreas) Gallbladder inflammation (cholecystitis) Cholelithiasis (gallstones) Gastroparesis (stomach paralysis) Syncope (fainting and loss of consciousness) Serious side effects should be reported to a healthcare provider immediately
However, we cannot completely rule out secondary effects on closely related cell signalling pathways such as ATR/Chk1 mediated DNA repair which can in part be influenced by reductions in ATM kinase activity 90,91
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