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Modifications are also being designed to create biased agonists

The trend is called microdosing GLP-1s, and its becoming more common

A: According to clinical trial data and FDA review: Clinical trials have studied GLP-1 medications for chronic weight management for up to 2-3 years, demonstrating acceptable safety profiles for most individuals during this timeframe

Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreas