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It isn't overly common, but the risk is greatly increased if you are taking more than one drug that has serotonergic effects The symptoms of serotonin syndrome include: Hyperthermia (increased body temperature) Hypertension (increased blood pressure) Muscle spasms Muscle rigidity Mental status changes (e.g., agitation, delirium, hallucinations, coma) The prescribing information for both phentermine and Adderall warn about serotonin syndrome and recommend not to combine them with other serotonergic agents

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These results show that although the expected therapeutic effect has not been achieved, AVV-based therapy has acceptable safety

doi: 10.1016/j.ejim.2023.04.005 27 ForzanoIVarzidehFAvvisatoRJankauskasSSMonePSantulliG