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Understanding individual response variability Genetic factors: Polymorphisms in genes encoding growth factor receptors, collagen synthesis enzymes, inflammatory mediators affect healing capacity and peptide responsiveness

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Effects beyond muscle While muscle growth receives the most attention, IGF-1 LR3 affects multiple tissue types throughout the body

Muscle Healing Animal studies on muscle transection models reported: Faster muscle fiber regeneration Reduced inflammatory markers Reference: Pevec et al., 2010 4