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Comparing Dose Escalation to Treatment Outcomes Clinical trial data shows weight loss of approximately 5% at doses around 1.0 mg weekly, with reductions increasing to 10-15% at the 2.4 mg maximum dose

doi: 10.1186/s40001-022-00833-6 102 HouM.ChenF.HeY.TanZ.HanX.ShiY.et al

If those sensations gradually become less noticeable, some may incorrectly assume the medication is no longer effective. "Our results suggest that patients may experience a partial return of appetite sensations over time, without losing the medication's benefit of continuing to reduce calorie intake, which is needed to maintain their new, lower body weight," Tronieri said