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The most commonly mutated genes are the potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11), ATP-binding cassette transporter, subfamily C, member 8 (ABCC8), and insulin (INS) genes

Specifically, the dithiol groups of Trx(SH) 2 can directly reduce oxidized proteins or provide electrons to thiol-dependent peroxidases (Prx) to convert hydrogen peroxide to water

Lifestyle & External Influences Stress: raises glucose Exercise: lowers glucose (watch for delayed lows) Alcohol: causes late-night hypoglycemia High-dose Vitamin C or Paracetamol: may distort readings in older sensors Clinical Pearl Two patients with the same HbA1c (7%) can have completely different CGM profiles One stable, the other with repeated highs and dangerous lows

Michailidou D, Gartshteyn Y, Askanase AD, Perl A