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They can also be taken once or twice daily at intervals of at least 6 hours to control symptoms

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They reported finding no genetic regions of loci associated with MVD, and they concluded that: "This analysis suggests that familial occurrence of mitral valve murmur in the CKCS breed is not due to a single major gene effect, indicating that breeding strategies to eliminate the disease cannot be based on genotype information at this time." In a December 2017 article, a team of 10 American cardiologists and geneticists examined the DNA in 10 cavaliers and 10 dachshunds diagnosed with MVD, searching for varients of genes known to be analogous to genetic mutations associated with MVD in humans