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Pharmacokinetics and pharmacodynamics of ranitidine in renal impairment

3 These rates appear higher than those seen with the injection, which may reflect the daily dosing pattern compared with once-weekly injections

Additionally, Rh4 elevated ROS accumulation, which activatedROS/p53 signaling pathway, thus demonstrating that Rh4 inhibits proliferation of cancer cell via promoting the ROS/p53 signaling pathway and inducing ferroptosis through autophagy (75)