The amino acids are linked in a distinctive series that provides the individual functions and characteristics of each peptide
This suggests low surface exposure or minimal contribution, which may indicate either highly exposed tyrosine in a hydrophilic environment (Aderinola et al., 2020) or enhanced energy transfer from tyrosine to tryptophan due to strong proteinprotein interactions (Malomo & Aluko, 2015)
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Interestingly, in the PREvencin con DIeta MEDiterrnea-Plus (Predimed-Plus) trial in overweight or obese individuals with metabolic syndrome, an increase in dietary choline intake over a one-year period was associated with improved measures of cardiovascular health (i.e., lower serum total cholesterol, serum LDL cholesterol, and systolic and diastolic blood pressure levels) (123)