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The quantitative bias analysis suggested that moderate unmeasured confounding could potentially explain away an HR of 0.86 observed with SGLT2 inhibitors versus DPP4 inhibitors, whereas stronger unmeasured confounding is needed to explain away larger HRs observed in as-treated analyses (Supplementary Fig

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Degradation accelerates at room temperature, meaning a 1mg dose from a two-month-old vial may contain significantly less active peptide than a fresh preparation