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Griffiths, K

Exclusion criteria Patients were excluded if they were younger than 18 years, pregnant or breastfeeding, or had medical conditions associated with altered redox homeostasis, including inflammatory, autoimmune, or chronic degenerative diseases

[16] showed a progressive decrease in ALC and other acyl-carnitines serum levels in people changing from normal to AD and concluded that the decreased serum concentrations of ALC and hence its disturbed functions may predispose to AD and contribute to neurodegeneration

While copper allergy appears rare, patch testing could be prudent for patients with a history of metal sensitivity or atopic dermatitis