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Results RaPID selection of anti-Met macrocycles and in vitro characterizations The RaPID system consists of the following techniques: (1) the flexizyme integrated translation (FIT) system 14 that facilitates genetic code reprogramming of non-proteinogenic amino acids and (2) messenger RNA display 15,16 that fuses the expressed peptide (phenotype) with its cognate mRNA (genotype), enabling amplification of activity-enriched phenotypes (Supplementary Fig
Among the remaining subjects, we further excluded those who received a diagnosis of bipolar disorder during the follow-up assessment (n = 9), those with missing metabolite data due to the lack of blood samples (n = 158) and those who did not complete the Inventory for Depressive Symptoms questionnaire (n = 33)
