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Increase IGF-1 Levels in as little as two weeks longer REM sleep and shorter sleep latency Increase fat-free muscle mass Decrease body fat percentage Stronger bones Improved endurance Increase nitrogen levels in the body Reversal of nitrogen wasting MOTS-C MOTS-c is a peptide encoded as an sORF in the mtDNA that is metabolically and developmentally regulated, which has endocrine-like effects on muscle metabolism, insulin sensitivity, and weight regulation establishes its role as a member of a new class of mitochondrial signals which can be called MDPs (Lee et al., 2013)

Quercetin can block the HMGB1/RAGE/NF-B axis to inhibit the release of pro-inflammatory factors such as TNF- and IL-6, target the NLRP3 inflammasome to block the maturation of IL-1/IL-18, and restore the balance of immune cell apoptosis by upregulating miR-204 to inhibit the HIF1/NFATc2 axis and the Src-STAT3-NFAT pathway (Rajabi et al., 2020