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Constipation is a common side effect and can be severe

For example, Motus (oral) by Tonum showed unusually large human clinical trial results for an oral supplement, with an average weight loss around 10.4 percent over six months

Epigenomics , 16 (3), 175188

Several factors that increase the induction of CYP2E1, including smoking, obesity, vinyl chloride, and exposure to trichloroethylene are associated with increased incidence of autism