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Chronic inflammation can Reduce flexibility of vein wall Cause malfunctioning of vein valve Reduce oxygen and nutrient supply to tissues Cause pain and swelling Increase the risk of blood clots All of these factors can contribute to varicose veins which can again lead to chronic inflammation

Safety evaluation of -lipoic acid supplementation: a systematic review and meta-analysis of randomized placebo-controlled clinical studies

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The RDA for protein (0.8g per kg of body weight) was not designed for patients losing weight rapidly on a drug that suppresses appetite and may impair muscle protein synthesis signaling