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On this basis, many studies have focused on the relationship between NAFLD and diabetes, supporting with growing evidence a bidirectional causative link between them and identifying insulin resistance as the key factor of this connection [24, 25]

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Although diabetes is widely accepted as one of the major risk factors for cardiovascular disease, the cardiovascular safety of antidiabetic drugs has been questioned due to the finding that intensive glycemic control by antidiabetic medications may result in an unexpected increase in cardiovascular death under certain circumstances [6]