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In contrast, a study comparing nateglinide with metformin demonstrated that metformin was more effective in lowering A1c levels (45)

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The mechanism by which GLP-1 receptor agonists might contribute to pancreatitis remains unclear, but may involve effects on pancreatic enzyme secretion or ductal pressure

Intriguingly, despite DL reducing plaque deposition, astrocytic and microglial activation in the DL mice was comparable to AL-fed mice, while pro-inflammatory gene expression was extremely high