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Elevated extracellular lactate, a defining feature of the tumor microenvironment, predicts poor outcomes, and high GPR81 expression correlates with poorer survival (8,53,54)

By doing so, it stimulates the secretion of growth hormone without significantly affecting other hormones like cortisol or prolactin

[DOI] [PMC free article] [PubMed] [Google Scholar] 140.Anticoli S., Amatore D., Matarrese P., De Angelis M., Palamara A.T., Nencioni L., Ruggieri A