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doi:10.1111/j.1085-9489.2006.00066.x 32

Nature 2002

These nerve-related changes can occur even without anemia being present, which means standard blood counts alone may not catch a developing deficiency

However, due to the large molecular size, topical glutathione may have limited skin penetration, though it can still support skin health when combined with other active ingredients like vitamin C, kojic acid, or niacinamide