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Clinically defined and diagnosed as having a body mass index (BMI) exceeding 30 kg/m 2 , the condition has rapidly risen in the global human population from 4% in 1975 to an astounding 18% (more than quadruple) in 2016

But it also increases hunger signals to compensate, and many women find that breastfeeding either has no effect on weight loss or actually makes it harder because the hunger it triggers exceeds the calories it burns

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The most common side effects are gastrointestinal: nausea (up to 44% in clinical trials), vomiting, diarrhea, and constipation, typically mild to moderate and decreasing over time