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Several studies have shown that high circulating blood levels of TMAO are associated with the development of many chronic diseases, including cardiovascular diseases (CVD), atherosclerosis 127 , obesity (potentially) 128 , diabetes, colorectal cancer 129 , acute kidney disease (AKD) ( Figure 2 ) 130 , and neurological disorders involving synaptic plasticity 131, 132

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Bone 154:116236 Paccou J, Thuillier D, Courtalin M, Pigny P, Labreuche J, Cortet B, Pattou F (2022) A comparison of changes in bone turnover markers after gastric bypass and sleeve gastrectomy, and their association with markers of interest