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This pulsatile pattern, combined with preserved somatostatin-mediated feedback, distinguishes ipamorelin from continuous GH delivery and is the reason it appears frequently in protocols designed to study pituitary axis regulation rather than simply elevate circulating GH

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Fagian MM, Pereira-da-Silva L, Martins IS, Vercesi AE (1990) Membrane protein thiol cross-linking associated with the permeabilization of the inner mitochondrial membrane by Ca 2+ plus prooxidants