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This study confirmed an association between use of semaglutide for type 2 diabetes and risk of NAION, with a more than two-fold increased hazard ratio. (3) A metanalysis of all clinical trials of glucagon-like peptide-1 receptor agonists, also known as GLP-1RA drugs, including Novo Nordisks own clinical trials, found an increased risk of optic ischemic neuropathy, although it did not reach a level of statistical significance

Trelle S, Reichenbach S, Wandal S, et al

Significant or rapid changes in body composition including those that can come with weight loss may make existing collagen loss more visible, more quickly