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From Gut Hormone to Wonder Drug If you strip away the hype, semaglutide is simply a clever copy of a natural hormone that tells the body youve eaten enough.[1] In the 1980s and 1990s, researchers discovered that the gut hormone GLP1 could lower blood sugar, slow digestion and curb appetite, but the natural hormone disappeared from the body within minutes.[2][3] So Novo Nordisk chemists spent years armouring GLP1tweaking its structure so it survived longer in the bloodstream and could be given as a weekly injection instead of a constant drip.[4][5] One of those tweaked versions was semaglutide, designed to stay active for around a week, which made it practical for realworld use in diabetes and, later, obesity.[6][7] Key point: A basic hormone signal from the gut was turned, stepbystep, into a longacting drug molecule that could be injected once a week

Successful weight reduction through these medications may actually decrease long-term thrombotic risk by addressing obesity as a modifiable risk factor