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The net result is a molecule that resists enzymatic breakdown considerably better than an unmodified sequence

Previous work by our laboratory has demonstrated the significant anti-fibrotic effects of TB001 in models of liver fibrosis ( 2 Materials and methods 2.1 Experimental animals and ethical statements Outbred rats (Sprague-Dawley [SD] and Wistar) and inbred rats (F344 and Lewis) were obtained from Beijing Vital River Laboratory Animal Technology Co., Ltd

In the B16F10 melanoma model, accelerated tumor progression occurs upon GRK2 downregulation, along with immature tumor vessel architecture, increased vessel perimeter, and tortuosity compared with that in wild-type (WT) mice (42)