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However, the precise mechanisms by which malonyl-CoA and cytosolic long-chain fatty acyl-CoA interactions result in reduced appetite are not fully characterized

The company said that in its most recent clinical trial, the discontinuation rate due to side effects increased with the dosage, with the highest discontinuation rate, 11.3%, at the highest dosage of 12 mg

Theyre kind of disadvantaged in multiple ways already and this is just one more way, said Wedad Rahman, an endocrinologist with Piedmont Healthcare in Conyers, Georgia

It is extrapolated from animal data and community experimentation, not from a human dose-finding trial