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Mounjaro (tirzepatide) Also a once-weekly injection, but tirzepatide targets both GLP-1 and GIP receptors a dual-action approach that has produced the strongest weight loss results seen in clinical trials to date (2025% average loss at the highest dose)

This points to a higher weight loss ceiling for retatrutide, though final conclusions await direct head-to-head clinical trials

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GLP-1, PYY, and/or oxyntomodulin to produce a superior appetite suppressing hormone profile that may result in a weight loss far exceeding that seen in single-agent trials