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The only clinically relevant difference between treatments was the higher frequency of gastrointestinal related adverse events with IcoSema versus icodec or semaglutide alone, which can be mitigated by appropriate dosing recommendations for IcoSema, as discussed above

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Clearing up controversies

The FDA at the time had similarly declared the end of a tirzepatides shortage, a move that the OFA also slammed as being without meaningful rationale. The OFAs complaint ended in failure, with the FDA last December affirming that the tirzepatide shortage was indeed over