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Elevated ROS levels in vitiliginous skin arise from environmental triggers (e.g., UV radiation and chemical exposure), impaired antioxidant enzyme activity, and mitochondrial dysfunction [77]

In: Branen AL, Davidson PM, Salminen S (eds) Food Additives

Were talking levels that equal potassium, glucose and cholesterol - which should give you some idea of how important it is, especially considering the sheer work or metabolic activity that goes in to creating it

Long interested in Holst's work, in 1990 Novo Nordisk recruited his colleague Schwartz to develop small molecules able to activate the GLP receptor in the pancreas (Molteni, Chen)