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Common Side Effects of Tirzepatide and Semaglutide The most frequently reported side effects include: Nausea (particularly during dose increases) Diarrhea or constipation Vomiting Abdominal discomfort Decreased appetite (expected effect) Most side effects occur during dose escalation and typically improve within 4-8 weeks as your body adjusts to the medication

doi: 10.1093/ndt/gfv409

Over-the-Counter (OTC) Laxatives and Stool Softeners If lifestyle changes arent providing sufficient relief, over-the-counter options can be effective for short-term use

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