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Research has confirmed that CD38 accumulation in ageing tissues is a primary driver of the age-related decline in NAD+ levels, with CD38 inhibition shown to restore NAD+ availability in pre-clinical models

The key nutrients with therapeutic effects mainly exert anti-inflammatory, anti-oxidative and chondro-protective effects

Additionally, the five-year follow-up of the ESCAPE trial confirmed that exercise-based physical therapy remained noninferior to APM for patient-reported knee function, suggesting that PT should be the preferred treatment over surgery for degenerative meniscal tears [Noorduyn et al, 2022]