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Description

Sildenafil stimulates the expression of gaseous monoxide-generating enzymes in vascular smooth muscle cells via distinct signaling pathways

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Concomitant use with coumarin anticoagulants such as warfarin has been associated with elevations in the international normalized ratio, requiring closer INR surveillance and potential dose adjustment

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Fue desarrollado por la empresa danesa Novo Nordisk a finales de los aos 1990 como parte de su programa de secretagogos de GH (NN703)

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